| Author | Message | ||
     Patrick |
I vaguely remember reading on some Web site that inflammed follicles are more susceptible to the negative effects of DHT. Is this true? What are some of the causes of scalp inflammation? Does AGA cause the inflammation or does inflammation have something to do with the onset of AGA? Are there any good remedies for an irritated or inflammed scalp? Would time in the sun help? | ||
| Tom Hagerty (Admin) |
DHT causes susceptible hair follicles to miniaturize. Dermatologists who have done skin biopsies in areas where there are miniaturized follicles in the scalp have seen inflammation around these follicles. This does not mean that the inflammation caused the miniaturization or the AGA. Perhaps skin flora colonize these miniaturized follicles. This in turn may elicit an immune response, and this immune system attack is responsible for the inflammation. The bacteria and fungus that might find a home in the follicles feed on the oil from the sebaceous glands; they also like the plant oils which are ingredients of some shampoos. Jojoba oil, by the way, is not liked by the bugs. Two things I would do to perhaps regain a healthy scalp: (1) Decrease the amount of animal fat in your diet - these fats may increase the sebum production in the sebaceous glands. (2) Don't use shampoos with sodium lauryl sulfate. These are too harsh for the scalp. Perhaps try Nizoral shampoo. | ||
| Stephen Foote |
I am interested in any detailed studies that may identify specific immunological changes in tissues linked to the action of DHT. Such immunological changes are suggested in my paper at www.biohydraulic.co.uk I am currently trying to get as much available data as possible about the immunological changes caused by DHT,and 5ARI's.Any links? Thanks S Foote. | ||
| Tom Hagerty (Admin) |
Stephen Foote: Before I give you some links which you may find helpful (this will take some time), I'd like you to give me some information. I just read the Abstract page on your Web site Biohydraulic and have two questions: (1)You wrote, "DHT is often referred to as a 'skin' hormone as much of the total quantity is produced in the periphery." My question is, exactly where in the periphery is the DHT produced? (2) You wrote, "Where DHT reduces hair growth, there is a reduction in sebum production." My experience has been that hair loss owing to DHT is usually accompanied by increased sebum production. Would you comment on this. Tomorrow I'm going to read through your entire Web site. It looks interesting. | ||
| Stephen Foote |
Dear Mr Hagerty,thank you for your response to my enquiry. The term "skin hormone"has been used in some text books in reference to DHT.The production of DHT in hair follicles and sebaceous glands is also refered to in the PDR data for Propecia(1999). As i understand it,a sebum "Flare"is often associated with a number of types of hairloss.This proposed "Hydraulic"mechanism could explain this.The evidence suggests however that this is a transitional condition,and my discussion of this relationship refers to the "Settled" situation. My paper is designed as an outline proposal.It describes a simple mechanism that would have an important purpose in the prime function of hair as an insulator.Of course if this is valid in humans,it will have to ultimately explain all the known "Details". I would like to emphasize however that one important question can be easily resolved at this time given the necessary data,(Please refer to the test proposal section of my paper).It is because of this prediction that i am trying to aquire any rellevant immunological data. Thank you for your interest. S Foote. | ||
| Tom Hagerty (Admin) |
Stephen Foote: You probably are aware of Keratin.com. Kevin j. McElwee, also from the UK, has a long! article on immunology which you will find on his table on contents. At the end of this article you will find Related Pages: Links to Academic Web Sites. Kevin is mostly interested in research pertaining to alopecia areata, but you will find much here related to AGA and the role that DHT plays. You are specifically interested in possible immunological changes associated with DHT. You may find some useful links on Kevin's site. |
