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bald wookie
Posted on Tuesday, June 13, 2006 - 01:50 am:   Edit Post Delete Post

If DHT is responsible for BPH[benign prostate hyperplasia] then it seems to be strange that DHT can also be used to REDUCE prostate size:

http://jcem.endojournals.org/cgi/content/full/83/8/2749


quote:

In patients with hypogonadotropic hypogonadism, DHT gel application resulted in virilization, increased muscle mass, and improved sexual function, without an increase in prostate size (14). When administered for a mean duration of 1.8 yr to older men (55–70 yr), DHT gel led to improved sexual function and a 15 percent decrease in prostate size (17). The explanation for the decreased prostate size was based on the observation that development of benign prostate hyperplasia in dogs (BPH) requires the synergistic stimulation of prostate stromal growth by local availability of both androgen (DHT) and estrogen (E2) (18, 19, 20, 21). Because DHT application suppressed gonadotropins, resulting in decreased endogenous T and E2 secretion, administration of DHT might result in significant decrease in size of the prostate because of the absence of the synergistic effect of intraprostatic E2 and/or intraprostatic DHT formation from T. There are other data in the rat, suggesting that DHT may be less likely than T to induce prostate pathology (22).




Does the combination of DHT AND [aromatased]estrogen cause baldness, not just DHT alone?


http://www2.ncsu.edu/ncsu/univ_relations/news_services/press_releases/96_10/hair .htm


quote:

Estrogen-Blocking Compound Found to Cause Hair Growth

Scientists at North Carolina State University have found that an estrogen-blocking compound used in their studies has an unexpected side effect: It induces hair growth in laboratory mice by stimulating inactive hair follicles.

Treating the mice with a biologically active estrogen was found to have the opposite effect: It blocks hair growth by locking follicles into a resting mode.

The discoveries suggest estrogen plays a much more important role in hair growth than scientists previously thought -- knowledge which ultimately could lead to new, more effective hair-loss treatments for humans.

[...]


 

bald wookie
Posted on Tuesday, June 13, 2006 - 02:11 am:   Edit Post Delete Post

Estrogen and ...water retention? scalp tissue edema?

http://www.ultrapms.com/pms/estrogen.htm


quote:

Estrogen also increases the level of the adrenal hormone aldosterone, which prevents the normal excretion of salt from the kidneys, adding to fluid retention. This creates edema-like symptoms of bloating, abdominal swelling, and swollen breasts






I wonder if S. Foote's hydraulic theory makes any new testable predictions?




http://en.wikipedia.org/wiki/Anti-androgen


quote:

Spironolactone (Aldactone, Spiritone), a synthetic 17-spirolactone corticosteroid, which is a renal competitive aldosterone antagonist


 

Anonymous
Posted on Tuesday, June 13, 2006 - 02:23 am:   Edit Post Delete Post

It's really hard to say because things like Propecia (which I believe is a DHT inhibitor) seems to work for some. I somehow get the feeling that a lot of the mechanisms of how drugs work are not fully revealed. For instance, when Minoxidil first came out there were so many crackpot theories as to why it worked.

Come to find out that Nitric Oxide is the (or one of the main) active ingredients. I feel that NO is all or most of what does it as far as Minoxidil. But without us knowing the role of Nitric Oxide in the body, we are/were in the dark. We would look towards Minox instead of finding alternative ways to boost NO.

You can see that propaganda and confusion of sorts could translate into lucrative business. If we were to find out every way in which certain drugs worked we would be able to find other cheaper, safer, and possibly more effective ways of treating things. The more we don't know, the better cash cows we make. I don't think it's too big of a stretch to think we are shown plenty of smoke and mirrors.
 

michael
Posted on Tuesday, June 13, 2006 - 04:39 am:   Edit Post Delete Post

WHAT WAS I TELLING YOU A COUPLE WEEKS AGO??!!

**********************************************

Merck is lying about finasteride.
Theyh claim finasterides protect from getting a cancer and prostate enlargment.

This is a complete fake. Men who develop prostate enlargement are over 40 or 50 or even 60 years old. In a young man body DHT protects prostate from getting enlarged. As man grow old and DHT levels are decreasing more and more estrogen is interacting with androgen receptors (also in prostate gland). Estrogens are responsible for prostate enlargement in the man in his middle age. Finasteride works completely different in the middle age man by counteracting with elevated levels of estrogen messing with men's prostate gland leading to its enlargement.


When young men take finasteride they open a gate for estrogens due to DHT defficiency. After a couple of years with finasteride prostate may even get inflammed and even get enlarged.(this happened to me)

This is something that Merck is not saying to anyone that biochemistry of a young and a middle age man differs so much so it can help 50 years old man but can also harm 20 years old boy.

*************************************************

I FOUND THESE RELATION ON MY HUMAN BODY NOT MICE!

DHT IS GOOD FOR PROSTATE!! 50 YEARS OLD MAN HAVE BPH BECAUSE OF DECREASE OF PROSTATE PROTECTIVE DHT AND ELEVATED ESTROGEN WHICH INCREASE PROSTATE AND ALSO KILL HAIR FOLICULES.

VERY LONG TERM USAGE OF DHT INHIBITORS MAY DISTURBE PROSTATE HEALTH, BECAUSE DHT IS GOOD FOR PROSTATE!!

THE DAMAGE WHICH IS DONE BY LONG TERM TERM USAGE OF DHT INHIBITORS IS "RECEPTOR SITE OVERSENSITIVITY"

IF YOU START GETTING SIDE EFFECTS FROM PROPECIA OR DUTASTERIDE IT MEANS THAT YOU IRREVERSIBLEY WORKED OUT DHT RECEPTORS OVERSENSITIVITY.

THIS MEANS THAT MOST NUTRIENTS, MINERALS, VITAMINS WHICH ARE NORMALY GOD FOR MAN'S HEALTH CAN BLOCK YOUR DHT RECEPTOR SITE IN YOUR PROSTATE AND BODY. PEOPLE WHO ARE NOT AWARE OF THIS PHENOMENON ESTABLISHED A FORUM ABOUT THEIR SIDE EFFECTS WHICH DID NOT STOP LONG TIME AFTER STOPING 5 ALFA REDUCTASE INHIBITORS. THEY STOPPED TAKING DRUG AND SWITCHED TO HEALTHY DIETS..ETC.. WITHOUT KNOWING THAT THEIR DHT RECEPTORS BECAME IRREVERSIBLY OVERSENSITIVE AND THEIR HEALTHY DIETS MESS WITH THEIR RECEPTORS.

REDICULOUS BUT TRUTH.
 

Gabe
Posted on Tuesday, June 13, 2006 - 05:39 pm:   Edit Post Delete Post

michael:

How do we fight hair loss then? reducing estrogen?
 

Anonymous
Posted on Tuesday, June 13, 2006 - 06:04 pm:   Edit Post Delete Post

That's one thing I always found peculiar. The fact that young man have the most Testosterone, hence the most DHT yet have the best hair. I always felt that in hairloss theories, there was too much conflict. Young men have all of this DHT and don't lose hair (typically) yet older men have reduced levels and in more instances suffer from MPB.

The notion that the body over time becomes more sensetive also seemed far fetched. It was however the easiest fit to making the theory work. I've read that estrogen was bad for hair- I've read that it was good for hair. A further example of what I stated earlier. Just as I've read that testosterone is bad for hair, and also that it was good. And I do believe things are like this on purpose.
 

SMAKKA MAKKA
Posted on Tuesday, June 13, 2006 - 06:05 pm:   Edit Post Delete Post

NO GABE, DONT BE AN ASS MAN! AND GET OFF THE ROIDS.
 

mj
Posted on Tuesday, June 13, 2006 - 06:42 pm:   Edit Post Delete Post

michael is crazy, thats all.
 

Dave
Posted on Tuesday, June 13, 2006 - 06:46 pm:   Edit Post Delete Post

I smoke rocks!
 

Anonymous
Posted on Tuesday, June 13, 2006 - 09:51 pm:   Edit Post Delete Post

Thanks for clearing that up.
 

pj
Posted on Wednesday, June 14, 2006 - 03:15 pm:   Edit Post Delete Post

Michael and wookie,

Have you guys ever considered that DHT and estrogen have to work TOGETHER to cause some of the bad things attributed to DHT alone medically?

We know castrates dont bald, and castration halts further balding. Propecia sees an increase in haircounts for the first two years, although youre back to where you started about a decade down the line. Thats pretty conclusive proof DHT has alot to do with baldness. Perhaps DHT and estrogen have a bad effect TOGETHER on a follicle. But women have tons of estrogen, and little DHT. They keep their hair.

I think focusing on keeping globulin, the sex-binding hormone, up........will save your hair from excessive testosterone and its metabolites (DHT, andro, DHEA, DHEAS) more than just screwing around with propecia anyway.

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