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Serum Ferritin Levels and Hair Loss

Here is the best article I've seen about relationship between low iron stores and hair loss. I hope I don't get into trouble copying and pasting most of this article from the informative website HairSite.com. I made a few comments which I inserted between brackets.

Iron Deficiency & Women's Hair Loss

One of the most common causes of hair loss in pre-menopausal women is not hormones, but a nutritional deficiency, with depleted iron stores [serum ferritin] being the most important factor.

In a study, one hundred and fifty three women who were diagnosed with telogen effluvium from 1995-1998 were examined. Seventy two percent (n=75) of women in the premenopausal group were found to have iron deficiency as the cause of telogen effluvium. Iron deficiency is defined as having a ferritin level of under 40ng/ml or iron percent saturation under 20%.

Iron deficiency is the most common cause of telogen effluvium in premenopausal women. Although medications are the most common cause of telogen effluvium in postmenopausal women, iron deficiency should not be ruled out.

Besides being a possible trigger for telogen effluvium where a lot of hair shedding occurs, iron deficiency could also be the most likely underlying cause when hair loss is subtle; slowly thinning out over many months or even years.

This is common among women of childbearing age due to menstruation and pregnancy. Iron is found mainly in the blood, and according to Dr Michael Sharon, author of Nutrients A-Z 'During one period, a woman will lose around 10-15 mg of iron, while throughout a pregnancy around 600-1000mg will be lost.'

Iron is the mineral that occurs in the greatest amount in the blood. The most important function of Iron in the human body is helping the production of both hemoglobin (the substance that carries oxygen within red blood cells) and myoglobin. Myoglobin is a form of hemoglobin found in muscles. Iron is also involved in the oxygenation of your body's red blood cells.

It is understood that levels of iron play a significant role in various body functions, however, it is also essential for the normal growth and maintenance of hair. If the amount of energy used up by the body is not replaced by food intake, then other non-essential stores will be used up. Unfortunately, this means the hair cells as they are not a vital part of living.

In order to maintain an adequate balance of iron in the body, the amount excreted must be replaced by the amount ingested in the diet. When the amount of dietary iron absorbed is insufficient, a negative iron imbalance occurs, and consequently iron stores are called upon to make up the deficit.

The fall of iron stores normally passes through several stages: lowered iron stores, iron depletion and iron deficiency anemia.

1) Lowered iron stores: This is indicated when the iron stores are reduced but not exhausted. No clinical effects are detected.

2) Iron depletion: Shows up in laboratory tests. Hemoglobin concentration may be well below ‘normal’ for that individual’s reference range. If the patient increases their iron intake, the hemoglobin may respond by increasing.

3) Iron deficiency anemia: No iron is left remaining in the bone marrow. Hemoglobin production falls to the point where concentration is well below the reference range.

It is important to note, therefore, that iron deficiency (low iron stores, i.e. low ferritin) can occur even if the patient is not clinically anemic and has normal haemoglobin levels

There may be a number of reasons why the amount of iron absorbed is not sufficient. Firstly, only about 10% of ingested iron is absorbed into the blood each day, and this is dependent on the type of food in the diet. Certain foods may inhibit the absorption of iron, such as tanins found in tea and coffee, also bran and egg albumin. Whereas other foods may be enhance the absorption of iron, i.e. vitamin C, alcohol, and flesh foods [red meat]. In general you can loose iron by: intestinal bleeding, excessive menstrual bleeding, poor digestion, long-term illness, ulcers, and heavy use of anti-acids. [Irritable bowel syndrome too]

Nutritionist Angel Dowden advises 'You can maximize your iron absorption by eating a combination of iron-rich foods such as red meat, green, leafy vegetables, shellfish, egg yolk, nuts and cereals with food or drinks that are high in vitamin C for example, a glass of freshly squeezed orange juice.

Avoid tea until at least an hour after eating as it contains tannin, which interferes with iron absorption.

One method of controlling iron deficiency in the body is to stimulate the liver to synthesize ferritin, the protein that stores iron in order to maintain the correct balance. Hair follicles are known to contain ferritin, and when the circulating stores of ferritin decline then these stores are called upon to ensure support for more essential cells, such as bone marrow. [See my comment at the end of this article.]

The loss of this ferritin from the follicle cells can effect the ability of the hair to grow. This leads to the development of vellus (non pigmented fine hairs) which can be an early indication of deficiency. The presence of vellus hairs is easily mistaken for miniaturized hair seen in androgenic alopecia. We should note here that Iron deficiency hair loss could therefore mimic the pattern of androgenic alopecia hair loss.

A lot of dermatologists may not agree to the fact that iron deficiency could be a major cause of hair loss, however most of them don't deny that it is an important contributing factor, besides, a lot of hair loss treatments may not work efficiently with low iron stores. Rushton suggests that serum ferritin concentrations of 40 ng/mL or greater are required for maintaining good hair while 70ng/ml is required for regrowth (Rushton DH. Management of hair loss in women. Dermatol Clinic)

Comment

The writer of this article said, "One method of controlling iron deficiency in the body is to stimulate the liver to synthesize ferritin, the protein that stores iron in order to maintain the correct balance." I wish he would have elaborated on this. Ferritin is a protein complex that contains about 23% iron. It's formed in the intestine when iron unites with a special protein called apoferritin. It is then stored in the body's tissues, especially the liver, spleen, and bone marrow.

Saturation, which is mentioned in this article, is the amount of hemoglobin present in a volume of blood compared to the normal value.

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